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Tazact (Piperacillin + Tazobactam)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
P735 Tazact (Piperacillin + Tazobactam) Cipla 1 injection 4gm+500 mg $58.50
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50
What is piperacillin and tazobactam?
Piperacillin is an antibiotic in a group of drugs called penicillins. Piperacillin fights bacteria in the body.

Tazobactam is in a similar group of antibiotic drugs and also fights bacteria in the body.

The combination of piperacillin and tazobactam is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.

Piperacillin and tazobactam may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about piperacillin and tazobactam?
Do not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), ticarcillin (Ticar, Timentin), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using piperacillin and tazobactam tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

What should I discuss with my healthcare provider before using piperacillin and tazobactam?
Do not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as:

amoxicillin (Amoxil, Augmentin);

ampicillin (Omnipen, Principen);

carbenicillin (Geocillin);

dicloxacillin (Dycill, Dynapen);

oxacillin (Bactocill);

ticarcillin (Ticar, Timentin); or

penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Before using piperacillin and tazobactam, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

kidney disease (or if you are on dialysis);

a bleeding or blood clotting disorder;

an electrolyte imbalance such as low levels of potassium in your blood;

cystic fibrosis;

a history of any type of allergy; or

if you are on a salt-restricted diet.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use piperacillin and tazobactam.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Piperacillin and tazobactam may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use piperacillin and tazobactam?
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Piperacillin and tazobactam is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Piperacillin and tazobactam must be mixed with a liquid (diluent) before injecting it. Shake the medication and diluent until well dissolved. Do not mix the medicine or draw your dose into a syringe or IV bag until you are ready to give yourself an injection. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

Piperacillin and tazobactam is usually given for 7 to 10 days, depending on the infection being treated. Follow your doctor's instructions.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using piperacillin and tazobactam.

Store unmixed piperacillin and tazobactam, and the liquid diluent, at cool room temperature. After mixing the medicine and diluent, you may store it at room temperature for up to 12 hours. Throw away any unused mixture that has not been used within that time. Mixed medication can also be stored in the refrigerator for up to 48 hours. Throw away any unused mixture that has not been used within that time.

What happens if I miss a dose?
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe anxiety, agitation, feeling restless or nervous, or seizure (convulsions).

What should I avoid while using piperacillin and tazobactam?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Piperacillin and tazobactam side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody;

easy bruising or bleeding, unusual weakness;

dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

fever, chills, body aches, flu symptoms; or

seizure (convulsions).

Less serious side effects may include:

nausea, vomiting, stomach pain or upset;

constipation;

headache;

anxiety, sleep problems (insomnia);

skin rash or itching;

pain, swelling, or other irritation where the injection was given; or

vaginal yeast infection (itching or discharge).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Piperacillin and tazobactam Dosing Information
Usual Adult Dose for Aspiration Pneumonia:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: Parenteral therapy should be continued until the patient's clinical condition stabilizes and fever subsides. Oral antibiotic therapy may then be substituted according to microbiology sensitivity data. Therapy of documented anaerobic pleuropulmonary infections should be continued until the infiltrate is cleared, or a residual scar forms, sometimes for as long as 2 to 4 months.

Usual Adult Dose for Bacteremia:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for approximately 14 days, depending on the nature and severity of the infection; once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data

In severe infections, piperacillin trough levels (drawn immediately before the 4th or 5th dose) may be helpful. Serum piperacillin trough levels greater than 16 mcg/mL have been associated with improved efficacy.

Usual Adult Dose for Deep Neck Infection:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for approximately 2 to 3 weeks, depending on the nature and severity of the infection; once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data

Usual Adult Dose for Endometritis:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain-free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued).

Usual Adult Dose for Febrile Neutropenia:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: Therapy should be continued for about 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient is afebrile for 24 hours after the absolute neutrophil count is greater than 500/mm3. The total duration of therapy depends on the nature and severity of the infection. Once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data.

In severe infections, piperacillin trough levels (drawn immediately before the 4th or 5th dose) may be helpful. Serum piperacillin trough levels greater than 16 mcg/ml have been associated with improved efficacy.

Usual Adult Dose for Intraabdominal Infection:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for 7 to 10 days, depending on the nature and severity of the infection; once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data

In severe infections, piperacillin trough levels (drawn immediately before the 4th or 5th dose) may be helpful. Serum piperacillin trough levels greater than 16 mcg/mL have been associated with improved efficacy.

Usual Adult Dose for Joint Infection:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: Therapy should be continued for approximately 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, 6 weeks or more, may be required for prosthetic joint infections. In addition, removal of the involved prosthesis is usually required.

Usual Adult Dose for Nosocomial Pneumonia:

Moderate to severe: 4.5 g IV every 6 hours
Duration: for 7 to 14 days, depending on the nature and severity of the infection

Initial empiric treatment with broad-spectrum coverage according to the hospital's and/or ICU's antibiogram is recommended if multidrug-resistant organisms are suspected.

If the causative organism is not Pseudomonas aeruginosa, the duration of treatment should be as short as clinically possible (e.g., as little as 7 days) to reduce the risk of superinfections with resistant organisms.

Usual Adult Dose for Osteomyelitis:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: Therapy should be continued for approximately 4 to 6 weeks, depending on the nature and severity of the infection. Chronic osteomyelitis may require additional oral antibiotic therapy, possibly for up to 6 months. Surgical debridement of devitalized bone is critical to the management of osteomyelitis.

Usual Adult Dose for Pelvic Inflammatory Disease:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for 7 to 10 days, depending on the nature and severity of the infection

If the patient is not pregnant, oral doxycycline therapy for 14 days should be considered to treat possible concurrent chlamydial infection. The patient's sexual partner(s) should also be evaluated.

Usual Adult Dose for Peritonitis:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin or Soft Tissue Infection:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia:

Moderate community-acquired pneumonia: 3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Pyelonephritis:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for approximately 14 days, depending on the nature and severity of the infection; once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data

Usual Adult Dose for Urinary Tract Infection:

3.375 g IV every 6 hours; 4.5 g IV every 8 hours has also been used
Duration: for approximately 7 to 10 days, depending on the nature and severity of the infection; once the patient is stable and able to tolerate oral medications, oral antibiotic therapy may be substituted according to microbiology sensitivity data

Usual Pediatric Dose for Appendectomy:

2 to 9 months: 80 mg-10 mg/kg piperacillin-tazobactam IV every 8 hours
9 months or older (less than 40 kg): 100 mg-12.5 mg/kg piperacillin-tazobactam IV every 8 hours

Pediatric patients weighing over 40 kg with normal renal function should receive adult dose.

Usual Pediatric Dose for Peritonitis:

2 to 9 months: 80 mg-10 mg/kg piperacillin-tazobactam IV every 8 hours
9 months or older (less than 40 kg): 100 mg-12.5 mg/kg piperacillin-tazobactam IV every 8 hours

Pediatric patients weighing over 40 kg with normal renal function should receive adult dose.

What other drugs will affect piperacillin and tazobactam?
Before using piperacillin and tazobactam, tell your doctor if you are using any of the following drugs:

probenecid (Benemid);

an antibiotic such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin, Neo-Fradin, Neo-Tab), netilmicin (Netromycin), streptomycin, tobramycin (Nebcin, Tobi);

a blood thinner such as warfarin (Coumadin); or

any other medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

This list is not complete and there may be other drugs that can interact with piperacillin and tazobactam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?
Your doctor or pharmacist can provide more information about piperacillin and tazobactam.

 

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