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Parkinson & Alzheimers
    Home > Parkinson & Alzheimers > Trivastal L.A. (Piribedil)
 

Trivastal L.A. (Piribedil)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
P885 Trivastal L.A. (Piribedil) Serdia 10 tabs 50 mg $13.68
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50
Indications
Treatment of Parkinson's disease (PD), either as monotherapy (without L-DOPA (Levodopa)) or in combination with L-DOPA therapy, in the early stages as well as in the advanced stages of the disease.

Treatment of pathological cognitive deficits in the elderly (impaired attention, motivation, memory, etc).

Treatment of dizziness in the elderly.

Treatment of retinal ischemic manifestations.

Adjuvant treatment in intermittent claudication due to peripheral vascular disease (PVD) of the lower limbs (stage 2).

Anhedonia and treatment-resistant depression in unipolar and bipolar depressives (off label). Additional research and uses

Has been shown to enhance working memory capacities in normal aging adults

In age-related memory impairment has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.

Enhances cognitive skill learning in healthy older adults

Showed a positive effect in restless legs syndrome

Dosage
Parkinson's disease

Administration of piribedil should be initiated with one tablet daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:

as monotherapy: three to five tablets in three to five doses daily.
in combination with L-dopa therapy: one to three tablets daily.

Other indications
One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.

Adverse effects
Minor gastrointestinal upset (nausea, vomiting, flatulence, etc) in predisposed individuals, or when taken between meals: adjust dosage individually, and/or add domperidone (Motilium).

Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness).

Interactions
Dopamine an
tagonists reduce the effect of piribedil.

Overdosage
At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone (CTZ). Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.

 

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