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    Home > Womens Health > Estriol (Evalon, Ovestin, Estradiol)

Estriol (Evalon, Ovestin, Estradiol)
J585 Estriol (Evalon, Ovestin, Estradiol) Organon 30 tabs 1 mg $10.66
J586 Estriol (Evalon, Ovestin, Estradiol) Organon 30 tabs 2 mg Fort $12.64
Out Of Stock J587 Estriol Cream (Evalon, Ovestin) Organon 1 X 15 gm tube 1 mg/g Ovestin Cream $22.00
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

How does it work?
Ovestin® (available in tablet or cream) is used predominantly for the relief of symptoms caused by atrophy of the lower urogenital tract following the menopause. These include general vaginal/urinary symptoms, recurrent infections of the vagina and lower urinary tract, and mild urinary incontinence.

Ovestin contains the natural hormone estriol, which is a weak estrogen. It treats urogenital symptoms without causing adverse changes to the endometrium, which means that it can be used without a progestogen in women with an intact uterus (with estrogen therapies containing estradiol, progestogens are given every month to induce a necessary protective shedding of the endometrial tissue, causing a monthly "withdrawal bleed"). The absence of progestogen-induced withdrawal bleeds with Ovestin makes it highly acceptable to women.

As well as treating symptoms, the treatment has a preventive effect, having been shown to increase resistance to vaginal infection and inflammation.

Ovestin is provided in a choice of three formulations—tablets, cream and pessaries—allowing patients to select the most appropriate form. A marked therapeutic effect typically occurs within several weeks of administration.

Womens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, and often affect the delicate lining of the vagina. Oestrogen deficiency can cause vaginal dryness, inflammation or itching, and this in turn can lead to sex being uncomfortable or painful, and to an increased susceptibility to vaginal or urinary infections.

Oestrogen can be given as a supplement to replace the falling levels in the body and help reduce the distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). Oestrogen (in this case in the form of estriol) can also be applied directly to the vagina in the form of vaginal cream, in order to directly supplement the vaginal tissues with oestrogen. This is known as topical HRT and is useful for relieving just the vaginal symptoms of the menopause.

What is it used for?
Hormone replacement therapy.

Women using any form of HRT should have regular medical and gynaecological check-ups. Your need for continued HRT should be reviewed with your doctor at least once a year.

It is important to be aware that women using HRT have an increased risk of being diagnosed with breast cancer compared with women who don't use HRT. This risk needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. You should discuss these with your doctor before starting HRT. Women on HRT should have regular breast examinations and mammograms and should examine their own breasts regularly. Report any changes in your breasts to your doctor or nurse.

It is important to be aware that women using HRT have a slightly increased risk of stroke and of blood clots forming in the veins (eg deep vein thrombosis/pulmonary embolism) compared with women who don't use HRT. The risk is higher if you have existing risk factors (eg personal or family history, smoking, obesity, certain blood disorders - see cautions below) and needs to be weighed against the personal benefits to you of using HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. Discuss these with your doctor before starting treatment.

The risk of blood clots forming in the veins (thromboembolism) while using HRT may be temporarily increased if you experience major trauma, have surgery, or are immobile for prolonged periods of time (this includes travelling for over five hours). For this reason, your doctor may recommend that you stop using HRT for a period of time (usually four to six weeks) prior to any planned surgery, particularly abdominal surgery or orthopaedic surgery on the lower limbs, or if you are to be immobile for long periods. The risk of blood clots during long journeys may be reduced by appropriate exercise during the journey and possibly by wearing elastic hosiery. Discuss this with your doctor.

Stop using this medicine and inform your doctor immediately if you experience any of the following symptoms while using this medicine: stabbing pains or swelling in one leg; pain on breathing or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness affecting one side or part of the body; fainting; worsening of epilepsy; migraine or severe headaches; visual disturbances; severe abdominal complaints; increased blood pressure; itching of the whole body; yellowing of the skin or eyes (jaundice); or severe depression.

There is a possibility that this cream may damage latex condoms, diaphragms and caps, and the effectiveness of these contraceptives may consequently be reduced. If you need to use contraception to prevent pregnancy because you could still be fertile, another non-hormonal method (eg contraceptive foam) should be used. (A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. This medicine should not be used by women who are pregnant.)

Use with caution in
Close family history of breast cancer (eg mother, sister or grandmother has had the disease)
History of benign breast lumps (fibrocystic breast disease)
History of fibroids in the womb
History of endometriosis
History of overgrowth of the lining of the womb (endometrial hyperplasia)
Personal or family history of blood clots in the veins (venous thromboembolism, eg deep vein thrombosis or pulmonary embolism)
Blood disorders that increase the risk of blood clots in the veins, eg antiphospholipid syndrome, factor V Leiden
Women taking medicines to prevent blood clots (anticoagulants), eg warfarin
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Personal or family history of recurrent miscarriage
Severe obesity
Varicose veins
History of high blood pressure (hypertension)
Raised levels of fats called triglycerides in the blood (hypertriglyceridaemia)
History of liver disease, eg liver cancer
Decreased kidney function
Heart failure
History of diabetes
History of gallstones
History of migraines or severe headaches
History of epilepsy
History of asthma
History of an ear disorder that may cause hearing loss (otosclerosis)
History of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of hormone preparations such as contraceptive pills (chloasma).



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