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Hormones & Transgender
    Home > Hormones & Transgender > Estriol Cream (Evalon, Ovestin)
 

Estriol Cream (Evalon, Ovestin)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
Out Of Stock J587 Estriol Cream (Evalon, Ovestin) Organon 1 X 15 gm tube 1 mg/g Ovestin Cream $22.00
J585 Estriol (Evalon, Ovestin, Estradiol) Organon 30 tabs 1 mg $10.66
J586 Estriol (Evalon, Ovestin, Estradiol) Organon 30 tabs 2 mg Fort $12.64
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

How does it work?
Ovestin vaginal cream contains the active ingredient estriol, which is a naturally occuring form of the main female sex hormone, oestrogen.

Womens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, and often affect the delicate lining of the vagina. Oestrogen deficiency can cause vaginal dryness, inflammation or itching, and this in turn can lead to sex being uncomfortable or painful, and to an increased susceptibility to vaginal or urinary infections.

Oestrogen can be given as a supplement to replace the falling levels in the body and help reduce the distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). Oestrogen (in this case in the form of estriol) can also be applied directly to the vagina in the form of vaginal cream, in order to directly supplement the vaginal tissues with oestrogen. This is known as topical HRT and is useful for relieving just the vaginal symptoms of the menopause.

Ovestin cream is inserted into the vagina using the applicator provided. It releases small amounts of oestrogen locally into the vaginal tissues and is used short-term to provide relief from the vaginal symptoms of the menopause, such as dryness, itching and irritation.

Ovestin cream may also be used to treat the vaginal tissues before and after vaginal surgery, for example for vaginal prolapse.

Estriol from Ovestin cream is absorbed from the vagina into the bloodstream, which means it may potentially be associated with the same risks as other forms of HRT and so carries the same warnings. These warnings are most relevent to repeated or long-term use of the cream. You can read more about the risks and benefits of HRT in the factsheet about the menopause linked below. To minimise the absorption of this medicine, the lowest dose to control symptoms should be used, and treatment should be stopped every two three months for four weeks to see if it is still needed. Treatment should be reviewed at least once a year with your doctor.

What is it used for?
Vaginal symptoms of the menopause (atrophic vaginitis)
Treating the vaginal tissues before and after vaginal surgery, eg for vaginal prolapse.

Warning!
Follow the instructions provided with your vaginal cream carefully. The cream should be inserted into the vagina using the applicator provided. It is usually best to do this before going to bed at night. Using oestrogen-only HRT tablets or patches for a long time can increase the risk of cancer of the lining of the womb (the endometrium). It is possible there may be a similar risk when oestrogen creams, pessaries or rings are used in the vagina for repeated treatments, or over a long period of time. If you experience any vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort during or after using Ovestin vaginal cream, you should consult your doctor so that this can be investigated.

Women using any form of HRT should have regular medical and gynaecological check-ups. Your need for continued HRT should be reviewed with your doctor at least once a year.

It is important to be aware that women using HRT have an increased risk of being diagnosed with breast cancer compared with women who don't use HRT. This risk needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. You should discuss these with your doctor before starting HRT. Women on HRT should have regular breast examinations and mammograms and should examine their own breasts regularly. Report any changes in your breasts to your doctor or nurse.

It is important to be aware that women using HRT have a slightly increased risk of stroke and of blood clots forming in the veins (eg deep vein thrombosis/pulmonary embolism) compared with women who don't use HRT. The risk is higher if you have existing risk factors (eg personal or family history, smoking, obesity, certain blood disorders - see cautions below) and needs to be weighed against the personal benefits to you of using HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. Discuss these with your doctor before starting treatment.

The risk of blood clots forming in the veins (thromboembolism) while using HRT may be temporarily increased if you experience major trauma, have surgery, or are immobile for prolonged periods of time (this includes travelling for over five hours). For this reason, your doctor may recommend that you stop using HRT for a period of time (usually four to six weeks) prior to any planned surgery, particularly abdominal surgery or orthopaedic surgery on the lower limbs, or if you are to be immobile for long periods. The risk of blood clots during long journeys may be reduced by appropriate exercise during the journey and possibly by wearing elastic hosiery. Discuss this with your doctor.

Stop using this medicine and inform your doctor immediately if you experience any of the following symptoms while using this medicine: stabbing pains or swelling in one leg; pain on breathing or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness affecting one side or part of the body; fainting; worsening of epilepsy; migraine or severe headaches; visual disturbances; severe abdominal complaints; increased blood pressure; itching of the whole body; yellowing of the skin or eyes (jaundice); or severe depression.

There is a possibility that this cream may damage latex condoms, diaphragms and caps, and the effectiveness of these contraceptives may consequently be reduced. If you need to use contraception to prevent pregnancy because you could still be fertile, another non-hormonal method (eg contraceptive foam) should be used. (A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. This medicine should not be used by women who are pregnant.)

Use with caution in
Close family history of breast cancer (eg mother, sister or grandmother has had the disease)
History of benign breast lumps (fibrocystic breast disease)
History of fibroids in the womb
History of endometriosis
History of overgrowth of the lining of the womb (endometrial hyperplasia)
Personal or family history of blood clots in the veins (venous thromboembolism, eg deep vein thrombosis or pulmonary embolism)
Blood disorders that increase the risk of blood clots in the veins, eg antiphospholipid syndrome, factor V Leiden
Women taking medicines to prevent blood clots (anticoagulants), eg warfarin
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Personal or family history of recurrent miscarriage
Severe obesity
Varicose veins
Smokers
History of high blood pressure (hypertension)
Raised levels of fats called triglycerides in the blood (hypertriglyceridaemia)
History of liver disease, eg liver cancer
Decreased kidney function
Heart failure
History of diabetes
History of gallstones
History of migraines or severe headaches
History of epilepsy
History of asthma
History of an ear disorder that may cause hearing loss (otosclerosis)
History of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of hormone preparations such as contraceptive pills (chloasma).

 

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