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Champix (Varenicline)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
J612 Champix (Varenicline) Branded Original 25 tabs 0.5mg $42.50
R900 Champix (Varenicline) Branded Original 28 tabs 1mg $45.00
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

How does it work?
Champix tablets contain the active ingredient varenicline, which is a medicine used to help people who are addicted to nicotine to give up smoking. It acts in the brain, but is not the same as nicotine replacement therapy.

Varenicline is a type of medicine called a nicotinic acetylcholine receptor partial agonist. This means that it acts on the same receptors in the brain as nicotine.

Varenicline works by stimulating the nicotinic receptors in the brain. This produces an effect that relieves the craving and withdrawal symptoms you can get when you stop smoking.

At the same time, varenicline blocks nicotine from acting on the nicotinic receptors. This prevents any nicotine inhaled in tobacco smoke from having a rewarding and enjoyable effect.

You should set a date on which you will stop smoking and start taking this medicine one to two weeks beforehand. This is because the medicine needs time to start working.

The dose is increased gradually in the first week of treatment (follow the instructions given by your doctor or pharmacist) and the medicine should then be taken twice a day for 12 weeks. If you have successfully managed to stop smoking at the end of 12 weeks, your doctor may offer you a further 12 week course of treatment.

The tablets should be swallowed whole with a drink of water. They can be taken with or without food.

You should seek help and support as much as possible while giving up smoking, even while taking this medicine, as this will increase your chance of success. Your doctor, practice nurse or local pharmacist can all provide this support.


What is it used for?

Aid for giving up smoking in adults.

Warning
This medicine might make you feel dizzy or sleepy and so could impair your ability to perform potentially hazardous tasks such as driving or operating machinery. You should avoid driving or operating machinery until you know how this medicine affects you and are sure that it won’t affect your ability to perform such activities safely.
There have been reports of suicidal thoughts or behaviour in people taking this medicine to help them give up smoking. It is very difficult to know if this is due to the medicine, as giving up smoking itself can make people depressed, especially if they already have a mental health problem, and depression is associated with suicidal thoughts. However, not all people experiencing depression and suicidal thoughts while taking this medicine had a previous history of psychiatric illness, or had stopped smoking. For this reason, if you begin to feel agitated or depressed, or experience any changes in your behaviour or thoughts about suicide or harming yourself during treatment with this medicine, you should stop taking it and consult your doctor immediately.
Some people may find that when they stop taking this medicine their urge to smoke returns. They may also feel irritable, depressed or have difficulty sleeping. To avoid this, your doctor may consider reducing your dose slowly when you finish treatment with this medicine, rather than stopping it abruptly. Discuss this with your doctor.


Use with caution in
Decreased kidney function.
History of psychiatric illness, eg depression, schizophrenia, bipolar disorder.
Epilepsy.


Not to be used in
Pregnancy.
This medicine is not recommended for children and adolescents under 18 years of age, as there is no information regarding its safety and efficacy in this age group.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.


Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The safety of this medicine for use during pregnancy has not been established. It should not be used by pregnant women. Seek further medical advice from your doctor.
It is not known if this medicine passes into breast milk, but it is possible that it may. As a result, it is not recommended for mothers who are breastfeeding. If you have been unable to give up smoking using any other method, you should discuss with your doctor whether it may be appropriate to stop breastfeeding in order to try this medicine. This will depend on factors such as the importance of breastfeeding to the child, how much smoke the child is being exposed to and how likely this medicine is to help you stop smoking. Seek medical advice from your doctor.


Side effects
Giving up smoking with or without treatment can cause various symptoms. These include changes in mood (such as feeling depressed, irritable, frustrated or anxious), difficulty sleeping or concentrating, decreased heart rate and increased appetite or weight gain.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with using this medicine to help give up smoking. It is not known if these side effects are a result of using the medicine, or a result of giving up smoking. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.


Very common (affect more than 1 in 10 people)


Nausea.
Headache.
Difficulty sleeping (insomnia).
Abnormal dreams.


Common (affect between 1 in 10 and 1 in 100 people)


Sleepiness or fatigue.
Dizziness.
Change in taste.
Dry mouth.
Disturbances of the gut such as constipation, diarrhoea, vomiting, abdominal discomfort or bloating, indigestion, wind (flatulence).
Increased appetite.


Uncommon (affect between 1 in 100 and 1 in 1000 people)


Decreased appetite.
Inflammation of the nose and throat (nasopharyngitis), sinuses (sinusitis) or lungs (bronchitis).
Feeling thirsty.
Shortness of breath, cough or hoarseness.
Throat irritation.
Runny nose.
Snoring.
Mood swings.
Abnormal thinking.
Changes in sex drive.
Tremor.
Abnormal co-ordination.
Problems with speech.
Restlessness or agitation.
Awareness of your heartbeat (palpitations) or abnormal heartbeats.
Abnormal intolerance of the eyes to light.
Skin reactions such as rash, itching or sweating.
Watery eyes.
Increased urination.
Chest pain.
Increased blood pressure or heart rate.
Increased weight.
Joint stiffness.
Feeling cold.


Unknown frequency (cases have been reported since the medicine has been on the market)


Depression.
Suicidal thoughts.
Heart attack.


The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.


How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

The safety and benefits of taking this medicine in combination with other medicines for stopping smoking have not been studied. Other smoking cessation medicines are therefore not recommended while you are taking this one. Using nicotine replacement therapy (NRT) in combination with this medicine has been shown to increase nausea, headache, vomiting, dizziness, indigestion, fatigue and a drop in blood pressure compared to NRT alone.

If you have severe kidney problems you should not take cimetidine in combination with this medicine, as it may increase the amount of varenicline in the blood.

The components of tobacco smoke can cause certain medicines, for example those listed below, to be removed from the body faster than normal. When you stop smoking, they are removed slower, so their blood levels may increase. This means that if you are taking any of these medicines, your doses may need adjusting after you stop smoking:


clozapine
dextropropoxyphene
flecainide
fluvoxamine
olanzapine
pentazocine
phenylbutazone
some benzodiazepines, eg oxazepam
some beta-blockers, eg propranolol
tacrine
theophylline
tricyclic antidepressants, such as imipramine
warfarin.


People with diabetes who smoke normally need more insulin, as smoking reduces the amount of insulin that is absorbed into the blood from an injection under the skin. If you have diabetes and are giving up smoking, you may subsequently need a reduction in your insulin dose. Discuss this with your doctor.

 

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