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Roliten 2mg (Tolterodine Tartarate)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
P1527 Roliten 2mg (Tolterodine Tartarate) Ranbaxy 10 tab 2mg $9.13
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

Usage of Roliten (2 mg)- Tolterodine Tartrate- Tablet

Tolterodine is a competitive muscarinic receptor antagonist with actions similar to atropine. It is used in the management of urge urinary incontinence (Over active bladder)., urgency and frequency.

When not to use Roliten (1 mg)- Tolterodine Tartrate- Tablet
Hypersensitivity.
Urinary and gastric retention.
Narrow-angle glaucoma.
Severe ulcerative colitis.
Toxic megacolon.
Pregnancy.
Caution when using Roliten (1 mg)- Tolterodine Tartrate- Tablet
Hepatic or renal impairment.
Autonomic neuropathy, hiatus hernia.
QT interval prolongation.
Known Side Effects of Roliten (1 mg)- Tolterodine Tartrate- Tablet
Dry mouth, constipation, vertigo/dizziness, abdominal pain, abnormal vision, urinary retention, xerophthalmia.
Headache, somnolence.

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Absorption
Peak plasma concentration in 1-3 hours. Absolute bioavailability: 17%; 65% (poor metabolisers).

Distribution
Protein-binding: Extensive (mainly to α1-acid glycoprotein). Half-life: 2-3 hours; 10 hours (poor metabolisers).

Metabolism
Metabolised mainly in the liver by the CYP2D6 to active 5-hydroxymethyl tolterodine (in extensive metabolisers accounting for majority of population). Poor metabolisers, accounting for 7% of population: Metabolised via CYP3A4 to inactive N-dealkylated metabolites. Clinical use not affected by metabolism differences as tolterodine and its CYP2D6-dependent metabolite, 5-hydroxymethyl tolterodine are equipotent.

Excretion
Excreted in the urine, mainly as metabolites and some as unchanged drug (<1%) and via faeces (17% ).
Tolterodine Indications / Tolterodine Uses

Tolterodine Adverse Reactions / Tolterodine Side Effects

Dry mouth, chest pain, headache, somnolence, fatigue, dry skin, abdominal pain, constipation, dyspepsia, diarrhoea, dizziness, anxiety, weight gain, abnormal vision, dry eyes, paraesthesia, nervousness, urinary retention.
Precautions

Overdosage
Symptoms: Severe central anticholinergic effects (e.g. hallucinations, severe excitation), accommodation disturbances, micturition difficulties and QT prolongation. Management: Treatment is symtomatic and supportive. Reduce absorption by gastric lavage and activated charcoal. Severe central anticholingeric effects may be treated with physostigmine. Mydriasis may be managed by pilocarpine eye drops and/or placing patient in dark room. Convulsions or marked excitation can be managed by benzodiazepines and β-blockers may be used in tachycardia.
Special Precautions

Bladder flow obstruction, GI obstructive disorders, renal or hepatic impairment, autonomic neuropathy, hiatus hernia, risk of decreased GI motility, patients at risk of QT interval prolongation (e.g. electrolyte disturbances, bradycardia, pre-exisiting cardiac disorder).
Other Drug Interactions

Increased risk of overdosage with potent CYP3A4 inhibitors e.g. macrolide antibiotics (erythromycin and clarithromycin), azole antifungals (e.g. ketoconazole and itraconazole), protease inhibitors, ciclosporin or vinblastine. Increased risk of torsade de pointes with drugs that prolong the QT interval (e.g. class Ia and class III antiarrhythmics). Increased risk of 'cholinergic neurogenic hypersensitivity' with centrally acting anticholinesterases (e.g. donepezil, rivastigmine). Increased risk of antimuscarinic side effects with antimuscarinic drugs.
 

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