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Gris OD (Griseofulvin)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
p927 Gris OD (Griseofulvin) Dr.Reddy's 30 tabs 375 mg $7.83
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

About Griseofulvin

Griseofulvin (also known as Grisovin, a proprietary name of Glaxo Laboratories) is an antifungal drug. It is used both in animals and in humans, to treat fungal infections of the skin (commonly known as ringworm) and nails. It is derived from the mold Penicillium griseofulvum.

It is administered orally.
Pharmacodynamics
Pharmacokinetics

Griseofulvin is a fungistatic antibiotic that inhibits fungal cell division at metaphase and binds to human keratin making it resistant to fungal infections. It has activity against common dermatophytes including epidermophyton, Microsporum, or Trichophyton spp.

Absorption
Variably and incompletely absorbed from the GI tract (oral), may be increased by decreasing particle size and admin with fatty meals; peak plasma concentrations after 4 hours.

Distribution
Keratin precursor cells, stratum corneum of the skin and nails. Protein-binding: 84%.

Metabolism
Hepatic; conveted to 6-demethylgriseofulvin and few glucuronide conjugates.

Excretion
Via urine (<1% as unchanged; 6-demethylgriseofulvin, and glucuronide conjugates), via faeces (large amount of reduced particle size), via sweat; 9-24 hours (elimination half-life).
Griseofulvin Indications / Griseofulvin Uses

Information Not Available
Griseofulvin Adverse Reactions / Griseofulvin Side Effects

Oral thrush; GI distress, taste perversion; dizziness, confusion, headache, depression, insomnia, fatigue; peripheral neuritis, photosensitivity; skin rashes, urticaria, erythema multiforme; leucopenia, proteinuria.

Potentially Fatal: Hepatotoxicity; angioedema.
Precautions

Patients on prolonged therapy with any potent medication should be under close observation. Periodic monitoring of organ system function, including renal, hepatic and hemopoietic, should be done.

Since Griseofulvin is derived from species of penicillin, the possibility of cross sensitivity with penicillin exists; however, known penicillin-sensitive patients have been treated without difficulty.

Since a photosensitivity reaction is occasionally associated with Griseofulvin therapy, patients should be warned to avoid exposure to intense natural or artificial sunlight. Should a photosensitivity reaction occur, lupus erythematosus may be aggravated.
Special Precautions

Lactation; may impair ability to drive or operate machinery; avoid exposure to intense sunlight or artificial light. Regular monitoring of the renal, hepatic and blood tests should be done.
Other Drug Interactions

Antagonises oral anticoagulants and oral contraceptives. Decreased GI absorption with phenobarbital. Reduced plasma concentrations with enzyme inducers e.g. phenylbutazone and hypnotics.

Potentially Fatal: Enhances effects of alcohol and causes disulfiram-like reaction.
Other Interactions

Food Interaction
High-fat meal enhances absorption
Dosage

Oral
Dermatophytosis
Adult: 0.5-1 g daily in single or divided doses for 2-8 weeks in hair and skin infections, 6 months in fingernail infections and 12 months or more for toenail infections.
Child: 10 mg/kg daily.
Food(before/after)

Should be taken with food. (Take immediately after meals.)
List of Contraindications
Griseofulvin and Pregnancy

Contraindicated in pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Griseofulvin and Lactation

Caution when used during lactation
Griseofulvin and Children

Information Not Available
Griseofulvin and Geriatic

Information Not Available
Griseofulvin and Other Contraindications

Severe liver disease; porphyria; monilial infection; SLE; pregnancy
Storage

Oral
Store at 15-30°C

 

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