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Budamate Inhaler (Budesonide 200 mcg + Formetrol Fumarate 6 mcg)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
P1025 Budamate Inhaler (Budesonide 200 mcg + Formetrol Fumarate 6 mcg) Lupin 1 Inhaler 200mcg+6mcg $21.02
P1018 Budecort Inhaler (Budesonide) Cipla 1 inhaler 100mcg/ 1dose $18.95
P1024 Budamate Inhaler (Budesonide 400 mcg + Formetrol Fumarate 6 mcg) Lupin 1 inhaler 400mcg+6mcg $25.38
P1023 Budamate Inhaler (Budesonide 100mcg + Formetrol Fumarate 6 mcg) Lupin 1 inhaler 100mcg+6mcg $15.70
P1019 Budecort Inhaler (Budesonide) Cipla 1 inhaler 200mcg/ 1dose $26.32
P1020 Budecort Rotacaps (Budesonide) Cipla 30 rotacaps 100mcg $7.79
P1021 Budecort Rotacaps (Budesonide) Cipla 30 rotacaps 200mcg $5.00
P1022 Budecort Rotacaps (Budesonide) Cipla 30 rotacaps 400mcg $8.46
J373 Budesonide Generic 1 inhaler 200 MDI $20.66
J273 Rhinocort (Budesonide) Generic 1 inhaler 100 mcg $22.45
J146 Foradil (Formoterol) Generic 30 caps 12 mcg $9.77
Out Of Stock P1034 Foratec (Formoterol) 12mcg Cipla 1 inhaler 120MDI $20.39
Out Of Stock P1035 Foratec (Formoterol) 12mcg Cipla 30 Rotacaps 12mcg $6.48
J437 Formoterol Generic 30 caps 12 mcg $10.66
P1038 Duova (Tiotropium Bromide 18 mcg+ Formoterol Cipla 15 Rotacaps 18mcg+12mcg $35.51
P1037 Duova Inhaler (Tiotropium Bromide 18 mcg + Formoterol Fumarate 12 mcg) Cipla 1 inhaler 120MDI $35.51
P1036 Duova Inhaler (Tiotropium Bromide 9 mcg + Formoterol Fumarate 12 mcg) Cipla 1 inhaler 120MDI $35.51
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

What is it?
Budamate Transhaler is a combination of budesonide, a potent glucocorticoid and formoterol, a selective long-acting beta-2-agonist. Budesonide is a potent glucocorticoid that binds with high affinity to the glucocorticoid receptor. It has a high ratio of topical to systemic activity. Formoterol is a very potent long-acting beta-2-agonist with a high intrinsic activity and a rapid onset of action.


Indication

Budamate Transhaler is indicated in the regular treatment of asthma, where use of a combination (long acting beta-2-agonist and inhaled corticosteroid) has been found to be appropriate. Symptomatic treatment of severe chronic obstructive pulmonary disease (COPD) with a history of repeated exacerbations despite regular therapy with long acting bronchodilators.


Dosage & Administration
Dosage is individual and adjusted according to disease severity. When control has been achieved, the dose should be titrated to the lowest effective dose, which could include Budamate Transhaler given once daily.


Asthma
Adults (18 years and older):
Budamate – 100/ 200 Transhaler
1 – 2 inhalations twice daily
Maximum dose is 4 inhalations twice daily


Budamate – 400 Transhaler
1 inhalation twice daily
Maximum dose is 2 inhalations twice daily


Adolescents (12-17 years):
Budamate – 100/ 200 Transhaler
1 – 2 inhalations twice daily


Budamate – 400 Transhaler
1 inhalation twice daily


Children (6-11 years):
Budamate – 100 Transhaler
1 – 2 inhalations twice daily


Budamate – 200 Transhaler
1 inhalation twice daily

Chronic Obstructive pulmonary Disease (COPD)
Budamate- 200 Transhaler
2 inhalations twice daily

Budamate – 400 Transhaler
1 inhalation twice daily

Contradictions
Budamate Transhaler is contraindicated in patients with a history of hypersensitivity to any of the component of the drug product.

Warnings & Precautions
Patients should be made aware that Budamate Transhaler must be used daily for optimum benefit, even when asymptomatic.

Budamate Transhaler should not be used to treat acute asthma symptoms for which a fast and short-acting bronchodilator is required. Patients should be advised to have their relief medication available at all times.

Sudden and progressive deterioration in control of asthma is potentially life threatening and consideration should be given to the need for increased therapy with corticosteriod.

As with all inhaled medication containing corticosteroids, Budamate Transhaler should be administered with caution in patients with pulmonary tuberculosis.

Budamate Transhaler should be administered with caution in patients with severe cardiovascular disorders, including heart rhythm abnormalities, diabetes mellitus, untreated hypokalaemia or thyrotoxicosis.

Potentially serious hypokalaemia may result from systemic agonist therapy but following inhalation at therapeutic doses plasma levels of formoterol are very low.

Paradoxical bronchospasm may occur. In such case Budamate Transhaler should be discontinued immediately, the patient assessed and alternative therapy instituted if necessary.

Systemic effects are much less likely to occur with inhaled corticosteroids than with oral corticosteroids. Possible systemic effects include adrenal suppression, growth retardation in children and adolescents, decrease in bone mineral density, cataract and glaucoma. It is important, therefore, that the dose is titrated to the lowest dose at which effective control is maintained.

Drug Interactions
Even though plasma levels of formoterol and budesonide are very low, potential interactions with other substrates or inhibitors of CYP3A4 cannot be excluded.

Both non-selective and selective beta-blockers should be avoided in patients with asthma, unless there are compelling reasons for their use.

Concomitant use of other beta-adrenergic containing drugs can have a potentially additive effect.

Pregnancy
Administration of Budamate Transhaler in pregnant women should only be considered if the expected benefit to the mother is greater than any possible risk to the foetus.

Lactation
Use of Budamate Transhaler in women who are breastfeeding should only be considered if the expected benefit to the mother is greater than any possible risk to the child.

Side Effects
As Budamate Transhaler contains formoterol and budesonide, the type and severity of side effects associated with each of the compounds may be expected. There is no incidence of additional effects following concurrent administration of the two compounds.

Side effects associated with -

Formoterol:
Tremor, palpitations and headache, have been reported, but tend to be transient and reduce with regular therapy.

Cardiac arrhythmias muscle cramps and hypersensitivity reactions, including rash, oedema and angioedema may occur in some patients.

Budesonide:
Hoarseness and candidiasis (thrush) of the mouth and throat can occur in some patients. Cutaneous hypersensitivity reactions have been reported.

Both hoarseness and incidence of candidiasis may be relieved by gargling with water after use of Budamate Transhaler.

Symptomatic candidiasis can be treated with topical anti-fungal therapy whilst still continuing with Budamate Transhaler.

Overdose
The signs and symptoms of Budamate overdose are tremor, headache and tachycardia. The preferred antidotes are cardioselective beta-blocking agents, which should be used with caution in patients with a history of bronchospasm. If higher than recommended dosage is continued over prolonged periods, some degree of adrenal suppression may result. Monitoring of adrenal reserve may be necessary.

 

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