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Anti Convulsants
    Home > Anti Convulsants > Nextop (Topiramate)
 

Nextop (Topiramate)
SELECT REF DESCRIPTION MANUFACTURER PACK SIZE STRENGTH OUR PRICE
P838 Nextop (Topiramate) Torrent 10 tabs 25 mg $4.29
P839 Nextop (Topiramate) Torrent 10 tabs 50 mg $6.97
J292 Topamax (Topiramate) Generic 10 tabs 25 mg $5.25
J293 Topamax (Topiramate) Generic 10 tabs 50 mg $10.12
J294 Topamax (Topiramate) Generic 10 tabs 100 mg $18.14
P840 Topirol (Topiramate) Sun Pharma 10 tabs 100 mg $10.57
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50
What is topiramate?
Topiramate is a seizure medication, also called an anticonvulsant.

Topiramate is used alone or in combination with other medications to prevent seizures in adults and children who are at least 2 years old.

Topiramate is also used to prevent migraine headaches. Topiramate will only prevent migraine headaches or reduce the number of attacks. It will not treat a headache that has already begun.

Topiramate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about topiramate?
Seek emergency medical attention if you have a sudden change in vision and pain around or behind the eyes. These may be early signs of a serious side effect of topiramate. Do not stop taking topiramate without first talking to your doctor, even if you feel better. You may have increased seizures if you stop taking topiramate suddenly. You will need to use less and less before you stop the medication completely. Contact your doctor if your seizures get worse or you have them more often while taking topiramate.

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Carry an ID card or wear a medical alert bracelet stating that you are taking topiramate, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication. Topiramate can cause side effects that may impair your vision or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Avoid drinking alcohol. It can increase some of the side effects of topiramate, and can also increase the risk of a seizure.

Ketogenic or "ketosis" diets that are high in protein and low in carbohydrates can increase the risk of kidney stones. Avoid the use of such diets while you are taking topiramate.

What should I discuss with my healthcare provider before taking topiramate?
Do not use this medication if you are allergic to topiramate.

Before taking topiramate, tell your doctor if you are allergic to any drugs, or if you have:

kidney disease or a history of kidney stones;

liver disease;

glaucoma;

asthma, emphysema, or bronchitis; or

if you have recently had surgery.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Topiramate can make birth control pills less effective. Talk with your doctor about other forms of birth control if you are trying to prevent pregnancy while taking topiramate. It is not known whether topiramate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take topiramate?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Topiramate can be taken with or without food.

Take the medicine with a full glass of water.

The topiramate tablet should be swallowed whole. It has a bitter taste when chewed or broken.

To make the topiramate capsule easier to swallow, you may open the capsule and sprinkle the medicine into a spoonful of applesauce, custard, ice cream, oatmeal, pudding, or yogurt. Swallow this mixture right away without chewing. Do not save the mixture for later use.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using topiramate. You may need to stop using the medicine for a short time.

Do not stop taking topiramate without first talking to your doctor, even if you feel better. You may have increased seizures if you stop taking topiramate suddenly. You will need to use less and less before you stop the medication completely. Contact your doctor if your seizures get worse or you have them more often while taking topiramate. Carry an ID card or wear a medical alert bracelet stating that you are taking topiramate, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication. Drink extra fluids each day while you are taking topiramate. This will lower your risk of having kidney stones or an electrolyte imbalance. Vomiting or diarrhea can lead to dehydration and cause an electrolyte imbalance. Call your doctor if you have ongoing vomiting or diarrhea while taking topiramate. Store topiramate at room temperature away from moisture and heat.

What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical treatment if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, dizziness, agitation or depression, blurred vision, problems with speech or balance, stomach pain, chest pain, fast or pounding heartbeats, feeling light-headed, fainting, and seizure (convulsions).

What should I avoid while taking topiramate?
Topiramate can cause side effects that may impair your vision or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Avoid drinking alcohol. It can increase some of the side effects of topiramate, and can also increase the risk of a seizure. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by topiramate. Tell your doctor if you regularly use any of these other medicines.

Ketogenic or "ketosis" diets that are high in protein and low in carbohydrates can increase the risk of kidney stones. Avoid the use of such diets while you are taking topiramate.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Drink extra fluids in these situations.

Topiramate side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Stop taking topiramate and call your doctor at once if you have any of these serious side effects:

sudden vision loss, pain around or behind your eyes;

dry mouth, increased thirst, confusion, drowsiness, decreased sweating, increased body temperature, and hot, dry skin,

nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions); or

severe pain in your side or lower back, painful or difficult urination.

Less serious side effects may include:

slowed thinking, memory problems, trouble concentrating;

problems with speech or balance;

numbness or tingling;

sleep problems (insomnia);

tired feeling;

headache, dizziness; or

loss of appetite, weight loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Topiramate Dosing Information
Usual Adult Dose for Migraine Prophylaxis:

Initial dose: 25 mg once a day in the evening.

In the second week, the dose may be titrated up to 25 mg twice a day, in the morning and in the evening.

In the third week, the dose may be titrated up to 25 mg in the morning and 50 mg in the evening.

In the fourth week, the dose may be titrated up to 50 mg in the morning and 50 mg in the evening.

The dose and titration should be guided by clinical outcome.

Longer intervals between dose adjustment may be used as needed.

Usual Adult Dose for Seizure Prophylaxis:

>=17 years: For use as adjunctive therapy for patients with partial onset seizures, or primary generalized tonic-clonic seizures:

Recommended dose (as adjunctive therapy): 200 mg/day to 400 mg/day in two divided doses. It is recommended that therapy be initiated at 25 to 50 mg/day followed by titration to an effective dose in increments of 25 to 50 mg/week. Titrating in increments of 25 mg/week may delay the time to reach an effective dose. Daily doses above 1,600 mg have not been studied.

In the study of primary generalized tonic-clonic seizures the initial titration rate was slower than in previous studies; the assigned dose was reached at the end of 8 weeks.

For use as initial monotherapy in patients with partial onset or primary generalized tonic-clonic seizures:

Recommended dose (as monotherapy): 400 mg/day in two divided doses. It is recommended that therapy be initiated at 25 twice a day followed by titration to an effective dose in increments of 50 mg/week (once weekly increases of 25 mg twice a day).

Usual Pediatric Dose for Seizure Prophylaxis:

2 to 16 years: For use as adjunctive therapy for patients with partial onset seizures, or primary generalized tonic-clonic seizures:

The recommended total daily dose of topiramate as adjunctive therapy is approximately 5 to 9 mg/kg/day in two divided doses. Titration should begin at 25 mg (or less, based on a range of 1 to 3 mg/kg/day) nightly for the first week. The dosage should then be increased at 1 or 2 week intervals by increments of 1 to 3 mg/kg/day (administered in two divided doses), to achieve optimal clinical response. Dose titration should be guided by clinical outcome.

In the study of primary generalized tonic-clonic seizures the initial titration rate was slower than in previous studies; the assigned dose of 6 mg/kg/day was reached at the end of 8 weeks.

>=10 years: For use as initial monotherapy in patients with partial onset or primary generalized tonic-clonic seizures:

Recommended dose (as monotherapy): 400 mg/day in two divided doses. It is recommended that therapy be initiated at 25 twice a day followed by titration to an effective dose in increments of 50 mg/week (once weekly increases of 25 mg twice a day).

What other drugs will affect topiramate?
Before taking topiramate, tell your doctor if you are taking any of the following medicines:

amitriptyline (Elavil, Etrafon);

atropine (Donnatal, and others);

benztropine (Cogentin);

glycopyrrolate (Robinul);

hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic);

methscopolamine (Pamine) or scopolamine (Transderm-Scop);

risperidone (Risperdal);

bladder or urinary medications such as darifenacin (Enablex), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

diabetes medicine you take by mouth, such as pioglitazone (Actos) or metformin (Actoplus Met, Avandamet, Glucophage, Fortamet);

glaucoma medications such as acetazolamide (Diamox), methazolamide (Neptazane), or dichlorphenamide (Daranide);

irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), propantheline (Pro-Banthine); or

other seizure medications such as carbamazepine (Carbatrol, Tegretol), lamotrigine (Lamictal), phenytoin (Dilantin), or valproic acid (Depakote, Depakene).

This list is not complete and there may be other drugs that can interact with topiramate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?
Your pharmacist can provide more information about topiramate.

 

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